INP/P5D Polyclonal Antibody_货号

Verified Samples in IHC:Mouse inflammation spleen,Rat thymus

IHC 1:200-1:1000

Polyclonal

IgG

KLH conjugated Synthetic peptide corresponding to Mouse SHIP1

INP/P5D

Inositol polyphosphate 5 phosphatase of 145kDa;4;5-trisphosphate 5-phosphatase 1;hp51CN;Inositol polyphosphate 5 phosphatase 145kDa;Inositol polyphosphate 5 phosphatase;Inositol polyphosphate-5-phosphatase of 145 kDa;INP/P5D;MGC104855;MGC142140;MGC142142;p150Ship;Phosphatidylinositol 3;4;5 trisphosphate 5 phosphatase 1;Phosphatidylinositol-3;SH2 containing inositol phosphatase isoform b;SH2 domain containing inositol 5' phosphatase 1;SH2 domain containing inositol phosphatase 1;SH2 domain-containing inositol phosphatase 1;SH2 domain-containing inositol-5''-phosphatase 1;SHIP-1;SHIP1;SHIP1;Signaling inositol polyphosphate 5 phosphatase SIP 145;SIP-145;SIP145抗体

Q9ES52,P97573

Cytoplasm. Membrane. Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate to membrane localization.

430 μg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

AF/FInity purification

Cancer; Immunology; Signal Transduction

Unconjugated

This gene is a member of the inositol polyphosphate-5-phosphatase (INP/P5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.