MAP2K2 Polyclonal Antibody 货号：

Verified Samples in WB: Hela, NIH/3T3, Jurkat
Verified Samples in IHC: Human gastric cancer, Human ovarian cancer

WB 1:1000-1:5000, IHC 1:100-1:300

Polyclonal

IgG

Synthetic peptide of human MAP2K2

MAP2K2

CFC syndrome, CFC4, Cardiofaciocutaneous syndrome, Dual specificity mitogen activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, MAPK / ERK kinase 2, MAPK/ERK k, map2k2

P36507

44 kDa

Cytoskeleton, microtubule, Cytosol, Endoplasmic reticulum, endoplasmic reticulum, Endosome, early endosome, late endosome, Extracellular region or secreted, extracellular region, Golgi apparatus, Golgi apparatus, Mitochondrion, Nucleus, Peroxisome, peroxisomal membrane, Plasma Membrane, cytoplasmic side of Plasma Membrane, Other locations: cell-cell junction, focal adhesion, perinuclear region of cytoplasm.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, pH 7.4.

Affinity purification

Cancer, Signal Transduction

Unconjugated

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.