Paraxanthine

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Paraxanthine

CAS No. : 611-59-6

MCE 国际站：Paraxanthine

产品活性：Paraxanthine，caffeine的代谢物，可通过刺激Ryanodine受体通道来抑制多巴胺能细胞的死亡。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：其他类

In Vitro: When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH⁺neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH⁺neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH⁺ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase).

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