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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
17650-84-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1413.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥450.0 |
| 规格： | 5 mg | 产品价格： | ￥1080.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
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Nicotiflorin
CAS No. : 17650-84-9
MCE 国际站：Nicotiflorin
产品活性：Nicotiflorin是从传统中药 Carthamus tinctorius 中提取的黄酮苷。Nicotiflorin具有有效的抗糖化 (antiglycation) 活性和神经保护作用。
研究领域：Others
作用靶点：Others
In Vitro: For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions.
In Vivo: At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits.
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