Rosmanol,80225-53-2

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Rosmanol

CAS No. : 80225-53-2

MCE 国际站：Rosmanol

产品活性：Rosmanol能够抑制低密度脂蛋白的氧化，显著抑制脂多糖诱导的 INOS、COX-2 的表达，并具有抗炎活性。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vitro: Rosmanol exhibits the strongest inhibition on cell viability with IC₅₀ approximately 42 μM. Rosmanol might suppress cancer cell proliferation or induce cancer cell undergoing apoptosis that lead to cell growth-inhibition. With 50 μM of Rosmanol treatment, the percentage of COLO 205 cells undergoing apoptosis increase dramatically from 9 h (29%) to 24 h (51%). Within 24 h of treatment with 50 μM Rosmanol, COLO 205 cells exhibit significant morphological changes and chromosomal condensation, which is indicative of apoptotic cell death. Carnosol is a lipid protector against attack by O₂.

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