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- MedChemExpress(MCE)
- 美国
- HY-N0706
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
19083-00-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥604.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥216.0 |
| 规格： | 5 mg | 产品价格： | ￥420.0 |
| 规格： | 10 mg | 产品价格： | ￥620.0 |
| 规格： | 25 mg | 产品价格： | ￥1030.0 |
| 规格： | 50 mg | 产品价格： | ￥1540.0 |
| 规格： | 100 mg | 产品价格： | ￥2240.0 |
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Gracillin
CAS No. : 19083-00-2
MCE 国际站：Gracillin
产品活性：Gracillin 是一种可以从植物的根里提取出来的甾体皂苷，有抗肿瘤的特性。Gracillin可诱导癌细胞凋亡 (apoptosis) 和自噬 (autophagy)。
In Vitro: Gracillin (0-10 μM, 6-24 h) shows broad-spectrum inhibitory effects on the cancer cell viability.
Gracillin (5 μM) disrupts mitochondrial function, specifically, inhibits ATP production, activates AMPK, inhibits oxygen consumption rate (OCR) in H460 and A549 cells.
Gracillin (0-10 μM, 6 h) induces ROS generation (indicated by H2DCF-DA) in H460, H1299, H226B and A549 cells.
Gracillin (0-4 μM, 24 h) blocks cell cycle in G1 phase, and induces apoptosis and autophagy in A549 cells.
In Vivo: Gracillin (oral gavage, 10 mg/kg for xenografts and 20 mg/kg for PDX) inhibits tumor growth of xenograft tumors inoculating lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors.
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