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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
59870-68-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 50 mg | 产品价格： | ￥1080.0 |
| 规格： | 100 mg | 产品价格： | ￥1600.0 |
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Glabridin
CAS No. : 59870-68-7
MCE 国际站：Glabridin
产品活性：Glabridin 是从 Glycyrrhiza uralensis 中分到的异黄烷类，能够结合并激活 PPARγ，EC50 值为 6115 nM。Glabridin 具有抗氧化、抗菌、抗肾炎、抗糖尿病、抗肿瘤、抗炎、抗骨质疏松、保护心血管、保护神经、清除自由基等作用。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Anti-infection
作用靶点：PPAR | Reactive Oxygen Species | Bacterial
In Vitro: Glabridin binds to and activates PPARγ, with an EC50 of 6115 nM.
?Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h.
?Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines.
?Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, ?8, and ?9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells.
In Vivo: Glabridin (50 mg/kg, p.o. once daily) shows potent anti-inflammatory activity, ameliorates the inflammatory alterations induced by Dextran sodium sulphate (DSS) in rats.
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