Epiberberine表小檗碱氯化物,889665-86-

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Epiberberine chloride

CAS No. : 889665-86-5

MCE 国际站：Epiberberine chloride

产品活性：Epiberberine chloride 是从黄连中得到的生物碱，为有效的 AChE 和 BChE 抑制剂，和非竞争性的 BACE1 抑制剂，IC₅₀ 值分别为 1.07，6.03 和 8.55 μM。Epiberberine chloride 具有抗氧化作用，能够清除 ONOO^- (IC₅₀，16.83 μM)，可用于阿尔滋海默症和糖尿病的研究。在 3T3-L1 细胞分化早期，Epiberberine 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。

研究领域：Neuronal Signaling  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：Cholinesterase (ChE)  |  Beta-secretase  |  Reactive Oxygen Species

In Vitro: Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC₅₀ of 52.8 μM.
Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation.
Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner.

In Vivo: Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice.

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