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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(S)-(+)-[6]Gingerol
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
23513-14-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥240.0 |
| 规格： | 10 mg | 产品价格： | ￥368.0 |
| 规格： | 25 mg | 产品价格： | ￥610.0 |
| 规格： | 50 mg | 产品价格： | ￥860.0 |
| 规格： | 100 mg | 产品价格： | ￥1240.0 |
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[6]-Gingerol
CAS No. : 23513-14-6
MCE 国际站：[6]-Gingerol
产品活性：[6]-Gingerol是从生姜中分离的活性物质，具有多种生物活性，包括抗癌，抗炎和抗氧化。
研究领域：Epigenetics | PI3K/Akt/mTOR | Apoptosis
In Vitro: [6]-gingerol inhibits colon cancer cell proliferation and induced apoptosis, while the normal colon cells are unaffected. [6]-gingerol down-regulates phorbol myristate acetate induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but has only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B. [6]-gingerol treatment is shown to restore impaired intestinal barrier function and to suppress proinflammatory responses in DSS-treated Caco-2 monolayers. AMPK is activated on [6]-gingerol treatment. Treatment with [6]-gingerol results in a significant decrease in the viability of osteosarcoma cells in a dose-dependent fashion. In parallel, the number of cells arrested at the sub-G1 cell cycle phase is significantly increased. [6]-gingerol induces activation of caspase cascades and regulates cellular levels of Bcl2 and Bax.
In Vivo: In animal studies, [6]-gingerol significantly ameliorates DSS-induced colitis by restoration of body weight loss, reduction in intestinal bleeding, and prevention of colon length shortening. In addition, [6]-gingerol suppresses DSS-elevated production of proinflammatory cytokines (IL-1β, TNFα, and IL-12).
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