Coelenterazine腔肠素,55779-48-1

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Coelenterazine

CAS No. : 55779-48-1

MCE 国际站：Coelenterazine

产品活性：Coelenterazine 是 apoaequorin 和 Renilla 荧光素酶的发光酶底物。Renilla 荧光素酶和底物 coelenterazine 被用作生物发光共振能量转移 (BRET) 中检测蛋白质-蛋白质相互作用的生物发光供体。Coelenterazine 是一种超氧阴离子敏感化学发光探针，其也用于过氧亚硝酸盐的化学发光检测 。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: HCT-8 control cells, transiently expressing Renilla luciferase (RLuc), showed low bioluminescence due to P-glycoprotein–mediated efflux transport of coelenterazine. By comparison, transiently expressing RLuc HCT-8 cells, wherein P-glycoprotein was down-regulated with shRNAi, showed high bioluminescence.

In Vivo: The in vivo growth potential of HCC1806-RR was monitored by injecting animals with coelenterazine (2 mg/kg) i.v. and exposing them to a charged-coupled device (CCD) camera 5 minutes later. Rluc activity was detected as light emitted from the tumor cells and acquired as a pseudo-color image superimposed over a black and white photograph of the animal. All mice demonstrated very high Rluc activity at the primary site with the majority of mice simultaneously showing metastases to inguinal ILNs.

相关产品：Acetylcysteine  |  H2DCFDA  |  Deferoxamine mesylate  |  Elesclomol  |  Quercetin  |  MitoSOX Red  |  L-Ascorbic acid  |  Mito-TEMPO  |  Mitoquinone mesylate  |  L-Glutathione reduced  |  Trolox  |  Zinc Protoporphyrin  |  FX-11  |  Dimethyl fumarate  |  Diphenyleneiodonium chloride  |  Berberine chloride  |  Urolithin A  |  TPEN  |  Sodium dichloroacetate  |  Tempol  |  2-Methoxyestradiol  |  GSK2795039  |  α-Vitamin E  |  Ciprofloxacin  |  Trabectedin  |  Coenzyme Q10  |  Piperlongumine  |  Chlorogenic acid  |  Ellagic acid  |  L-Ascorbic acid 2-phosphate trisodium

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds