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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, protect from light, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2558205-28-8
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1160.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2800.0 |
| 规格： | 10 mg | 产品价格： | ￥4600.0 |
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AkaLumine hydrochloride
CAS No. : 2558205-28-8
MCE 国际站：AkaLumine hydrochloride
产品活性：AkaLumine hydrochloride 是荧光素的一个类似物，其对重组荧光蛋白的 Km 值为 2.06 μM。
研究领域：Others
作用靶点：Fluorescent Dye
In Vitro: In both LLC/luc and MDA-MB-231/luc cells treated with AkaLumine hydrochloride, the signal is maximal at lower concentrations (by 2.5 μM), whereas the bioluminescence generated by D-luciferin and CycLuc1 increase as concentrations increase further, not appearing to reach a maximal signal even at 250 μM.
In Vivo: AkaLumine hydrochloride displays greatly enhanced signals emanating from metastasis in the lung, as demonstrated by 8.1-fold higher with AkaLumine hydrochloride as compared with D-luciferin administration. To evaluate the advantage of AkaLumine hydrochloride over CycLuc1 in detecting targets in deep tissue, bioluminescence images are compared between AkaLumine hydrochloride- and CycLuc1-treated mice 15 min after intravenous injection of LLC/luc cells at the dose of 5 mM, which is the maximum concentration of CycLuc1 due to its low water solubility. AkaLumine hydrochloride exhibits 3.3-fold increase in detection sensitivity of disseminated cancer cells in the lung compared with CycLuc1. The advantage of AkaLumine hydrochloride is further confirmed by imaging the same mice bearing lung metastasis after intraperitoneal injection of 5 mM substrates in order of CycLuc1 and AkaLumine hydrochloride, and in the inverse order at an 8-h interval. AkaLumine hydrochloride displays about fourfold increase in signals from lung metastasis compared with CycLuc1.
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