Ustekinumab乌司奴单抗乌司奴单抗,815610-6

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Ustekinumab

CAS No. : 815610-63-0

MCE 国际站：Ustekinumab

产品活性：Ustekinumab 是一种抗 IL-12/IL-23 的人源单克隆 IgG1κ 抗体。

研究领域：Immunology/Inflammation

作用靶点：Interleukin Related

In Vitro: Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (K_D) is calculated relative to Ustekinumab (Ustekinumab=1.0).

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