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CAS No. : 77465-10-2
MCE 国际站:Adrenocorticotropic Hormone (ACTH) (1-39), rat
产品活性:Adrenocorticotropic Hormone (ACTH) (1-39), rat 是一种有效的黑皮质素 2 型受体 (melanocortin 2 receptor, MC2) 激动剂。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Melanocortin Receptor
In Vitro: ACTH 1-39 at concentrations of 100-400 nM has no toxic effect on neurons, while ACTH provides protection from excitotoxic neuronal death induced by glutamate (100 μM), NMDA (1 mM), AMPA (50 μM), and kainate (25 μM). ACTH at 400 nM provides substantial protection in each case. ACTH at either 200 or 400 nM protects neurons from quinolinic acid (25 μM). There is also protection by ACTH from cell death induced by 2 μM H2O2, which gives rise to reactive oxygen species (ROS), with significantly more protection at 400 nM ACTH compared to 200 nM. ACTH gives modest protection against rapid release of nitric oxide (NO) by NOC-12 but not slow release by NOC-18. ACTH (200 or 400 nM) protects neurons from cytotoxic effects of staurosporine (10-20 nM), a classic inducer of cell death via apoptosis. ACTH reduces cell death from 80% to 55%.
In Vivo: The icv injection of ACTH significantly reduces cumulative food intake over the observation period compared with the saline/IgG group. The injection of ACTH Ab into the PVN abolishes the anorexigenic effect of ACTH. Infusion icv of ACTH significantly decreases cumulative food intake in rats that receive α-MSH Ab into the PVN and ACTH icv, and food intake is as low as in the group treated with ACTH icv and IgG into the PVN. Injection of either ACTH Ab or α-MSH Ab into the PVN significantly increase cumulative food intake compared with IgG-treated animals; the combined application of both Ab’s do not increase food intake further.
相关产品:α-MSH | SHU 9119 | THIQ | Bremelanotide Acetate | PF-00446687 | JNJ-10229570 | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | ACTH (11-24) | β-Melanocyte Stimulating Hormone (MSH), human TFA | HS014 TFA | RO27-3225 TFA | ACTH (1-17) (TFA) | Nonapeptide-1 acetate salt | Adrenocorticotropic Hormone (ACTH) (4-10), human | HS024 TFA | SNT-207707 | SNT-207858 free base | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | Fenoprofen | PG106 TFA | γ-1-Melanocyte Stimulating Hormone (MSH), amide | γ1-MSH | BMS-470539 dihydrochloride | CCZ01048 | CCZ01048 TFA | Dersimelagon
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