- ￥1713 - 5388
- MedChemExpress(MCE)
- 美国
- HY-W013332A
- 2025年12月05日
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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
86583-19-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2597.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1713.0 |
| 规格： | 5 mg | 产品价格： | ￥3900.0 |
| 规格： | 10 mg | 产品价格： | ￥5388.0 |
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3-Deazaadenosine hydrochloride
CAS No. : 86583-19-9
MCE 国际站：3-Deazaadenosine hydrochloride
产品活性：3-Deazaadenosine (hydrochloride) 是一种 S-腺苷高半胱氨酸水解酶 (S-adenosylhomocysteine hydrolase) 抑制剂，Ki 值为 3.9 µM；3-Deazaadenosine (hydrochloride) 具有抗炎、抗增殖、抗 HIV 等活性。
研究领域：Anti-infection
作用靶点：HIV
In Vitro: 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC50s of 0.15 and 0.20 μM, respectively.
3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.
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