Sitafloxacin西他沙星,127254-12-0

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Sitafloxacin

CAS No. : 127254-12-0

MCE 国际站：Sitafloxacin

产品活性：Sitafloxacin (DU-6859a) 是一种有效的口服活性氟喹诺酮类抗生素。 Sitafloxacin 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin 可用于呼吸道感染和尿路感染的研究。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Sitafloxacin (DU6859a) shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parC mutant 1026523 streptococcus pneumoniae stran, respectively.
Sitafloxacin (DU6859a) shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively.
Sitafloxacin (DU6859a) shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC₅₀s of 4.38, 3.12 mg/L, respectively.

In Vivo: Sitafloxacin (DU-6859a) (12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling.

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