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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1264-72-8
- 规格：
10 mM * 1 mL/100 mg/500 mg/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
| 规格： | 500 mg | 产品价格： | ￥800.0 |
| 规格： | 1 g | 产品价格： | ￥1200.0 |
| 规格： | 5 g | 产品价格： | ￥2400.0 |
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Colistin sulfate
CAS No. : 1264-72-8
MCE 国际站：Colistin sulfate
产品活性：Colistin是一种多肽抗生素，其通过与革兰氏阴性细菌的外细胞膜中的脂多糖和磷脂结合来抑制革兰氏阴性细菌。
研究领域：Anti-infection | Autophagy
作用靶点：Bacterial | Autophagy | Antibiotic
In Vitro: Colistins are bactericidal to gram-negative bacteria by a detergent-like mechanism. This mechanism involves interaction with lipopolysaccharides and phospholipids of the outer membrane and electrostatic interference with the outer membrane by competitively displacing divalent cations (calcium and magnesium) from the negatively charged phosphate groups of membrane lipids. Colistin (polymyxin E) owns favorable properties of rapid bacterial killing, a narrow spectrum of activity, and an associated slow development of resistance for the treatment of infections caused by multidrug-resistant gram-negative bacteria. There are two forms of colistin available commercially: colistin (sulfate) mainly for topical use and colistin methanesulfonate (sodium) for parenteral use.
In Vivo: High concentrations of colistin in rat ELF are achieved as a result of slow and sustained CMS conversion following i.t. instillation. Colistin is often used in piglets but underdosing and overdosing are frequent. Under- or overdoses of colistin do not result in any major disturbance of piglet fecal microbiota and rarely select for chromosomal resistance in the dominant E. coli population.
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文献和实验规范》，规定了目前允许使用的饲料药物添加剂，计有二硝托胺、马杜霉素铵、尼卡马嗪、乙氧酰胺苯甲脂、甲基盐霉素、抄沙诺西钠、氢溴酸常山酮、盐酸氯苯胍、盐酸氨丙啉、乙氧酰胺苯甲脂、碘胺喹恶啉、氯羟吡啶、海南霉素钠、赛杜霉素钠、地克珠利、复方硝基酚钠、氨苯胂酸、洛克沙胂、莫能菌素钠、杆菌肽锌、黄霉素、维吉尼亚霉素、喹乙醇、那西肽、阿美拉霉素、盐霉素钠、硫酸粘杆菌素、牛至油、吉它霉素、土霉素钙、金霉素、恩拉霉素预混料共33种。上述产品必须在产品标签上标明所含兽药成分的名称、含量、适用范围、停药期及注意事项。农业
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Perfringens菌epsilin抗毒素冻干粉 标准品 1,020 IU /ampoule. 磺酸甲烷黏菌素冻干粉 标准品 12,700 IU / mg, Approximately 75mg of colistin methane sulfonate. 黏菌素冻干粉 标准品 20,500 IU / mg, Approximatley 75mg of colistin Sulfate. 猪促肾上腺皮质激素（ACTH） 标准品 5 IU / ampoule 人C-反应蛋白冻干粉 标准品 0.049 IU
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