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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
MK-1439
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1338225-97-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥545.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
| 规格： | 25 mg | 产品价格： | ￥3900.0 |
| 规格： | 50 mg | 产品价格： | ￥5612.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Doravirine
CAS No. : 1338225-97-0
MCE 国际站：Doravirine
产品活性：Doravirine (MK-1439) 是一种高度特异性的 HIV-1 非核苷逆转录酶抑制剂，对野生型以及 K103N 和 Y181C 逆转录酶突变体的 IC50 值分别为 4.5 nM，5.5 nM 和 6.1 nM。
研究领域：Anti-infection
作用靶点：HIV | Reverse Transcriptase
In Vitro: Selectivity and cytotoxicity studies confirmed that Doravirine is a highly specific nonnucleoside reverse transcriptase inhibitors with minimum off-target activities. In the presence of 50% normal human serum (NHS), Doravirine shows excellent potency in suppressing the replication of WT virus, with a 95% effective concentration (EC95) of 20 nM, as well as K103N, Y181C, and K103N/Y181C mutant viruses with EC9595 of 43, 27, and 55 nM, respectively. Doravirine exhibits similar antiviral activities against 10 different HIV-1 subtype viruses (a total of 93 viruses).
In Vivo: Administration of 50 mg Doravirine with a high-fat meal is associated with slight elevations in AUC time zero to infinity and C24 h with no change in Cmax.
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