Elbasvir,1370468-36-2

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Elbasvir

CAS No. : 1370468-36-2

MCE 国际站：Elbasvir

产品活性：Elbasvir (MK-8742) 是丙型肝炎病毒非结构蛋白5A (HCV NS5A) 抑制剂， 对基因型1a，1b和2a的 EC₅₀ 分别为4，3 和3 nM。

研究领域：Anti-infection

作用靶点：HCV

In Vitro: Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC₉₀ of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC₉₀ of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC₅₀s in the low-picomolar range.

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