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- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
PTK 0796 tosylate; Amadacycline tosylate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1075240-43-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3848.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1188.0 |
| 规格： | 5 mg | 产品价格： | ￥2400.0 |
| 规格： | 10 mg | 产品价格： | ￥3840.0 |
| 规格： | 25 mg | 产品价格： | ￥7690.0 |
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Omadacycline tosylate
CAS No. : 1075240-43-5
MCE 国际站：Omadacycline tosylate
产品活性：Omadacycline (PTK 0796) tosylate，首创的具有口服活性的氨基甲基环素抗菌剂，是一种四环素类抗生素。Omadacycline tosylate 通过与 30S 核糖体亚基结合来抑制细菌蛋白质的合成。Omadacycline tosylate 对多种细菌表现出活性，包括好氧和厌氧革兰氏阳性细菌和革兰氏阴性细菌，非典型病原体。Omadacycline tosylate 可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively.
Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux.
Omadacycline (10 μM) inhibits the ligand binding activity of muscarinic acetylcholine receptor (M2) by 82%.
In Vivo: Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg.
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