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- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, protect from light, stored under nitrogen
- 英文名：
AAI101
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1001404-83-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥342.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
| 规格： | 100 mg | 产品价格： | ￥6500.0 |
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Enmetazobactam
CAS No. : 1001404-83-6
MCE 国际站：Enmetazobactam
产品活性：Enmetazobactam (AAI101) 是一种广谱的 β-内酰胺酶 (β-lactamase) 抑制剂，能够抵抗很多耐药革兰氏阴性细菌。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: Enmetazobactam shows potent activity against specific resistance phenotypes with MIC50 and MIC90 of 0.125 mg/L and 64 mg/L. Cefepime-Enmetazobactam MICs decreases with increasing concentrations of Enmetazobactam (over the range from 1 to 16 mg/L) for most strains, demonstrating a concentration dependence of Enmetazobactam on restoration of the antibacterial activity of the cephalosporin.
In Vivo: In neutropenic animals, cefepime-Enmetazobactam treatment results in reductions in bacterial density of ≥0.5 log10 CFU for 12 of the 20 strains tested and reductions of ≥1 log10 CFU for 6 of these. Increases in bacterial density are for only four strains, three of which have cefepime-Enmetazobactam MICs of ≥64 mg/L, irrespective of the Enmetazobactam concentration.
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