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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
952849-76-2
- 规格：
5 mg/10 mg/25 mg/50 mg
| 规格： | 5 mg | 产品价格： | ￥1300.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥2080.0 |
| 规格： | 25 mg | 产品价格： | ￥3550.0 |
| 规格： | 50 mg | 产品价格： | ￥5064.0 |
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KKL-10
CAS No. : 952849-76-2
MCE 国际站：KKL-10
产品活性：KKL-10是一种具有广谱抗菌活性的小分子核糖体拯救抑制剂。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.
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