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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C, stored under nitrogen
- 英文名：
GSK'547
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2226735-55-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥798.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥395.0 |
| 规格： | 5 mg | 产品价格： | ￥915.0 |
| 规格： | 10 mg | 产品价格： | ￥1563.0 |
| 规格： | 25 mg | 产品价格： | ￥2663.0 |
| 规格： | 50 mg | 产品价格： | ￥3838.0 |
| 规格： | 100 mg | 产品价格： | ￥5450.0 |
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GSK547
CAS No. : 2226735-55-1
MCE 国际站：GSK547
产品活性：GSK547 (GSK'547) 是一种高效的选择性 receptor-interacting serine/threonine protein kinase 1 (RIPK1) 抑制剂，可抑制巨噬细胞介导的胰腺癌适应性免疫耐受。
研究领域：Apoptosis
作用靶点：RIP kinase
In Vitro: GSK547 (0.1-100000 nM; 24 hours) pretreats L929 cells with recombinant TNFα and zVAD at various doses for 30 min, then cell death is induced with an IC50 of 32 nM after 24 hours.
?GSK547 up-regulates STAT1 signaling in bone marrow-derived macrophages (BMDM).
In Vivo: GSK547 (GSK′547; RIP1i) robustly targets RIP1 in vivo. RIP1 inhibition results in immunogenic macrophage differentiation in pancreatic cancer, leading to adaptive immune activation and tumor protection for pancreatic ductal adenocarcinoma (PDA).
?GSK547 (100 mg/kg/day; fed via food-based dosing; 15-50 days) reduces tumor burden and extends survival compared with mice treated with controls or Nec-1s.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Necrostatin-1 | GSK-872 | Necrostatin 2 racemate | GSK2982772 | GSK583 | GSK-843 | GSK840 | RIPA-56 | RIP1/RIP3/MLKL activator 1 | WEHI-345 | GSK2983559 | PROTAC RIPK degrader-2 | Apostatin-1 | GSK3145095 | HS-1371 | GSK2593074A | GSK963 | PROTAC RIPK degrader-6 | RIPK3-IN-1 | Eclitasertib | ICCB-19 hydrochloride | OD36 | GSK481 | PK68 | RIP1 kinase inhibitor 1 | RIPK-IN-4
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文献和实验DNA extraction from Mutation Detection Enhancement (MDE) Gel Stained with Silver Nitrate
'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â phosphorylation. The PCR conditions consisted of 1 cycle at 95˚C for 5 min; 40 cycles at 95˚C for30 sec, 55˚C for 45 sec, and 72˚C for 75 sec; at a final
dithiothreitol distilled water to 10 ml disburse into 500 ml aliquots and store at -20oC 1 M KCl Stock* 74.55 g KCl distilled water to 1 liter store at room temperature 10 M NaOH Stock* 40 g NaOH distilled water to 100 ml
DNA extraction from Mutation Detection Enhancement (MDE) Gel
DNA polymerase (Cinagen, Tehran, IRAN). The primers used were 3-A (5'-TAGTCACTGGCAACAGTCTT-3') and 3-B (5'-AAAATCCCTGTTCCCACTCATAC¨C3'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â
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