- ￥700 - 3938
- MedChemExpress(MCE)
- 美国
- HY-50855B
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
CX-4945 sodium salt
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1309357-15-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥1050.0 |
| 规格： | 50 mg | 产品价格： | ￥2625.0 |
| 规格： | 100 mg | 产品价格： | ￥3938.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Silmitasertib sodium salt
CAS No. : 1309357-15-0
MCE 国际站：Silmitasertib sodium salt
产品活性：Silmitasertib sodium salt 是一种有效、可口服、高度选择性的 CK2 抑制剂，对 CK2α 和 CK2α' 的 IC50值均为 1 nM。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Autophagy
作用靶点：Casein Kinase | Autophagy
In Vitro: Silmitasertib (CX-4945) causes cell-cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells, attenuates PI3K/Akt signalingand, and the antiproliferative activity of Silmitasertib (CX-4945) is correlated with expression levels of the CK2α catalytic subunit, Attenuation of PI3K/Akt signaling. Silmitasertib (CX-4945) with PS-341 treatment prevents leukemic cells from engaging a functional UPR in order to buffer the PS-341-mediated proteotoxic stress in ER lumen, and decreases pro-survival ER chaperon BIP/Grp78 expression. Silmitasertib (CX-4945) induces cytotoxicity and apoptosis, and exerts anti-proliferative effects in hematological tumors by downregulating CK2 expression and suppressing activation of CK2-mediated PI3K/Akt/mTOR signaling pathways.
In Vivo: Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Antiviral Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Endoplasmic Reticulum Stress Compound Library | Orally Active Compound Library | Rare Diseases Drug Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | LY294002 | Silmitasertib | IWP-2 | Emodin | Ellagic acid | D4476 | Umbralisib | PF-670462 dihydrochloride | TBB | TMX-4116 | Casein Kinase inhibitor A51 | DMAT | PF-4800567 | (E/Z)-GO289 | SR-3029 | SSTC3 | IC261 | TAK-715 | FPFT-2216 | CKI-7 free base | SGC-CK2-1 | CK1-IN-1 | TTP 22 | BTX161 | AMG-548 dihydrochloride | BioE-1115 | Hematein | TA-01 | MRT00033659 | CK2/ERK8-IN-1
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验NEJM 实锤：吃盐还是低钠的好！中国超 2 万人群研究提示
, Frieden TR. Dietary sodium and cardiovascular disease risk — measurement matters. N Engl J Med 2016;375:580-6.3. Marklund M, Singh G, Greer R, et al. Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt
PNAS 重磅：高盐饮食也能有益健康，它对自身免疫性疾病有显著的保护作用
性硬化症（MS）。有研究表明高盐饮食通过改变肠道菌群和增强 TH17 细胞分化，从而加剧了人工诱导的中枢神经系统自身免疫疾病。然而目前并没有证据表明盐的摄入与自发性自身免疫疾病相关。 2021 年 3 月 15 日，德国马克思普朗克生化研究所 Gurumoorthy Krishnamoorthy 团队在 PNAS 上在线发表题为 High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier
柳叶刀：刷新认知！少吃盐并不能降低心力衰竭的死亡风险，但仍有这些好处……
导读 作为赋予食物灵魂的调味品，盐在「舌尖上的美食」中发挥着不可替代的作用。但是越来越多的研究提示食用盐摄入量的增加与高血压、心血管疾病和过早死亡的风险增加有关。 前期，北京大学临床研究所武阳丰教授团队联合国内外多家研究机构曾在顶级医学期刊《新英格兰医学期刊》（NEJM）发表了题为：Effect of Salt Substitution on Cardiovascular Events and Death 的研究，通过大型整群随机对照试验，证实了长期食用低钠盐具有减少卒中、主要心血
技术资料暂无技术资料 索取技术资料
