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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
1639792-20-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5949.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1560.0 |
| 规格： | 5 mg | 产品价格： | ￥3900.0 |
| 规格： | 10 mg | 产品价格： | ￥6000.0 |
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Saroglitazar magnesium
CAS No. : 1639792-20-3
MCE 国际站：Saroglitazar magnesium
产品活性：Saroglitazar magnesium 是一种新型的过氧化物酶体增殖物活化受体PPAR的激动剂，具有显著PPARα活性和中度PPARγ活性，在HepG2细胞中的EC50值分别为0.65 pM and 3 nM。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor
作用靶点：PPAR
In Vivo: In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes.
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文献和实验Magnesium (Mg), the second most abundant soft tissue intracellular cation in vertebrates, is an essential nutrient for all organisms. Because of its small ionic radius and relatively large charge, Mg2+ functions within living cells primarily
Mg。原子量 24.3。是所有动物、植物不可缺少的元素。在植物中它是叶绿素的主要金属成分，如果缺镁，绿色植物就发生白化。非绿植物绝缺镁也同样是不行的。在高等植物中，镁是存在叶片里，特别是积存在脂肪种子中，无隔藻属缺镁时，一般细胞内油滴的形成消失，所以推测它与脂肪的代谢有关。对已糖激酶等磷酸转移酶、三磷酸腺苷酶等磷酸酶，以及谷氨酰胺合成酶等各种酶的活化，镁也是不可缺少的，也有人认为酶的主体是镁蛋白。镁在动物体内也广泛存在，在人体作为组成元素镁占第 11位（占体重的 0.05％）。是从食物中
The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis
TRPM7 and its closely related protein TRPM6 are unique bifunctional molecules consisting of a kinase domain fused to an ion channel. The ion channel belongs to the transient receptor potential (TRP) family of ion channels, TRPM subfamily
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