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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1001908-89-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1237.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥545.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥2970.0 |
| 规格： | 50 mg | 产品价格： | ￥4158.0 |
| 规格： | 100 mg | 产品价格： | ￥5821.0 |
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SRT 2183
CAS No. : 1001908-89-9
MCE 国际站：SRT 2183
产品活性：SRT 2183 是一种选择性 Sirtuin-1 (SIRT1) 激活剂，其 EC1.5 值为 0.36 μM。SRT 2183 诱导生长停滞和凋亡，同时伴随 STAT3 和 NF-κB 去乙酰化，并降低 c-Myc 蛋白水平。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Apoptosis
In Vitro: SRT 2183 (1-10 μM; 24-72 hours) inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner.
SRT 2183 (5-10 μM in Reh cells; 10 μM in Ly3 cells; 24 hours) induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels.
SRT2183 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival.
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文献和实验loops by gene mutation enhances SRT synthesis. We demonstrate that gene loop conformation enforces transcriptional directionality on otherwise bidirectional promoters.
3' (三)血友病APCR基因诊断程序 1.母亲、先证者的RFLP及Amp-FLP，确定风险染色体 2.检测胎儿性别(SRT) 3.检测胎儿的RFLP及AmP-FLP 四、散发病例FVⅢ基因突变的PCR检测 由于因子FVⅢ的基因突变以点突变为主，而且具有高度特异性，因此，单独网点 突变的检测方法仍以诊断，对于形发病例来说，可用PCR-SSCP，PCR-DGGE及其它的点 突变是筛查方法确定点突变血友病A之间的关系具有重要意义，尤其是PCR
HPLC‐SEC Characterization of Membrane Protein‐Detergent Complexes
Figure 29.5.5 Optimization of HPLC‐SEC: impact of column pre‐equilibration with a buffer containing high detergent concentration. A Sepax SRT‐500 column, 7.8 × 300 mm, was used for fractionation. Dashed line
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