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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1314891-22-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1105.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥450.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 25 mg | 产品价格： | ￥3103.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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TMP195
CAS No. : 1314891-22-9
MCE 国际站：TMP195
产品活性：TMP195是选择性的IIa类组蛋白脱乙酰酶 (HDAC) 抑制剂，对HDAC4，HDAC5，HDAC7，HDAC9的 Ki 值分别为59，60，26，5 nM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：HDAC
In Vitro: TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures. TMP195 significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle group. In the transcriptional profiling data from the PHA-stimulated PBMC experiments, CCL2 and CCL1 are respectively down- or upregulated by TMP195. TMP195 occupies the acetyllysine-binding site of class IIa HDACs. TMP195 competes against binding of HDAC7 to a variety of side-chain modifications on the same peptide backbone, despite no interference with the activity of other acetyllysine reader proteins BRD4 (IC50>50 μM).
In Vivo: TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors. Combining TMP195 with chemotherapy regimens or T-cell checkpoint blockade in this model significantly enhances the durability of tumour reduction.
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文献和实验1.2.1 尿素试验 参考Christtensen尿素肉汤培养和mlorris等快速诊断法,先用2%液体尿素常规法,后用10%液体尿素1min检查法及5%尿素滤纸片法,进行了对比研究。 1.2.2 直接涂片镜检 用保存液将胃粘膜研磨成匀浆后，取一滴推成涂片，甲醇固定后用0.3%碱性复红单染，于显微镜下直接检查。 1.2.3 幽门螺杆菌培养 以布氏琼脂培养基为基础，加入6%脱纤维新鲜羊血及联合抗生素（TmP5mg/L、万古霉素6mg/L、两性霉素2mg/L），制成血平皿，放置4°
快速解酒，还可减轻酒精伤害！中国团队开发的重组益生菌，或成为新型「解酒神器」
治疗效果是否在人类中具有安全性和有效性。 题图来源：站酷海洛 参考资料： [1] GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018 Sep 22;392(10152):1015-1035
0:10 内容简介10 0:21 订阅内容21 0:42 目的蛋白的表达和纯化、泛素标记42 3:15 免疫沉淀反应195 4:51 SDS-PAGE电泳和免疫染色291 5:48 体外检测蛋白质泛素化348 7:02 代表性结果422 8:22 结论502 蛋白质泛素化检测本视频来源于网络，如有异议请联系我们，我们将在5个工作日内作出处理。
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