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- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Bleomycin sulfate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
9041-93-4
- 规格：
5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥813.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥1302.0 |
| 规格： | 25 mg | 产品价格： | ￥2343.0 |
| 规格： | 50 mg | 产品价格： | ￥3280.0 |
| 规格： | 100 mg | 产品价格： | ￥4592.0 |
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Bleomycin sulfate
CAS No. : 9041-93-4
MCE 国际站：Bleomycin sulfate
产品活性：Bleomycin sulfate 是一种 DNA 损伤剂，抑制 DNA 合成。Bleomycin sulfate 是一种抗肿瘤抗生素 (antibiotic)。
研究领域：Cell Cycle/DNA Damage | Anti-infection
作用靶点：DNA/RNA Synthesis | Antibiotic
In Vitro: Bleomycin (BLM) sulfate is chosen as the best-studied micronucleus (MN) inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation.
The IC50 value of Bleomycin sulfate for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin (BLM); IC50 values are 14.2±2.8 nM and 13.0±1.1 nM, respectively.
Bleomycin sulfate (50, 100 μM; for 24, 48 h) induce pulmonary fibrosis in RLE-6TN cell (50 μM) and A549 cell (100 μM).
In Vivo: Bleomycin sulfate treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study.
Bleomycin sulfate (3.5-4.0 mg/kg; intra-tracheal) produces a statistically significant increase in lung hydroxyproline levels, and also increases right caudal lung lobe mass.
Bleomycin sulfate (intratracheal instillation; 5.0 mg/kg/day) induces pulmonary fibrosis in eighty 8-week-old male BALB/c mice with weight about 20-30 g. Bleomycin induces the expression levels of α-SMA and collagen I.
Bleomycin sulfate (intratracheally; 2.5 mg/kg; 1.25 mg/ml, approximately 50 μl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8 weeks old, average weight approximately 24.5 g).
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文献和实验5.9 1.7 4.3 硫唑嘌呤 azathioprine 60 betamethasone 72 4.8 64 2.9 1.4 5.6 博莱霉素 bleomycin - 68 - 1.1 0.27 3.1 布美他尼 bumetanide 81 62 99 2.6 0.13 0.8 布比卡因 bupivacaine - 2 95 7.1 0.9 2.4 咖啡因 caffeine 100 1.1 36 1.4 0.61
微球中平阳霉素的含量及组织中分布情况，考察磁性微球的靶向性。 关键词 HPLC 磁性微球 鼠肝组织 平阳霉素 平阳霉素(Pingyangmycin,PYM)系博来霉素(Bleomycin)A5组分，对鳞状细胞癌有独特的疗效，但对细胞的作用选择性不强，易引起严重的系统性毒副作用。为了使药物达到特定的部位发挥治疗作用，减少不良反应的发生，我们把平阳霉素制成磁性微球，进行大鼠肝动脉灌注，用外加磁场，考察其靶向性。本文报道用HPLC法测定磁性微球及鼠肝组织中的平阳霉素。 1 仪器与试药
72 4.8 64 2.9 1.4 5.6 博莱霉素 bleomycin - 68 - 1.1 0.27 3.1 布美他尼 bumetanide 81
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