APY29,1216665-49-4

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APY29

CAS No. : 1216665-49-4

MCE 国际站：APY29

产品活性：APY29 是 ATP 竞争性抑制剂，一种特异性的 IRE1α 别构调节剂，通过结合到 ATP 结合口袋来抑制 IRE1α 的自主磷酸化，IC₅₀ 值为 280 nM。APY29 也可以变构激活 IRE1α 相邻 RNase 域。

研究领域：Cell Cycle/DNA Damage

作用靶点：IRE1

In Vitro: APY29 divergently modulates the RNase activity and oligomerization state of IRE1α. APY29 is exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α.

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