Rosiglitazone罗格列酮,122320-73-4

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Rosiglitazone

CAS No. : 122320-73-4

MCE 国际站：Rosiglitazone

产品活性：Rosiglitazone (BRL 49653) 是一种具有口服活性的 PPARγ 选择性激动剂 (EC₅₀: 60 nM, K_d: 40 nM)。Rosiglitazone 是一种 TRPC5 激活剂 (EC₅₀: 30 μM) 和 TRPM3 抑制剂。Rosiglitazone 可用于肥胖、糖尿病、衰老、卵巢癌的研究。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor  |  Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Autophagy  |  Apoptosis

作用靶点：PPAR  |  TRP Channel  |  Autophagy  |  Ferroptosis  |  Apoptosis

In Vitro: Rosiglitazone (0.1-10 μM, 72 h) results in pluripotent C3H10T1/2 stem cell differentiation to adipocytes.
Rosiglitazone (1 μM, 24 h) activates PPARγ, which binds to NF-α1 promoter to activate gene transcription in neurons.
Rosiglitazone (1 μM, 24 h) protects Neuro2A cells and hippocampal neurons against oxidative stress, and up-regulates BCL-2 expression in an NF-α1-dependent manner.
Rosiglitazone (0.01-100 μM, 15 min) inhibits TRPM3 with IC₅₀ values of 9.5 and 4.6 μM against nifedipine- and PregS-evoked activity respectively.
Rosiglitazone (0.5-50 μM, 7 days) inhibits ovarian cancer cell proliferation.
Rosiglitazone (5 μM, 7 days) suppresses Olaparib (HY-10162) induced alterations of cellular senescence and promotes apoptosis in A2780 and SKOV3 cells.

In Vivo: Rosiglitazone (oral administration, 5 mg/kg, daily for 8 weeks) decreases the serum glucose in diabetic rats.
Rosiglitazone (intraperitoneal injection, 3 mg/kg/day) ameliorates airway inflammation induced by cigarette smoke via inhibiting the M1 macrophage polarization by activating PPARγ and RXRα in male Wistar rats.
Rosiglitazone (intraperitoneal injection, 10 mg/kg, once every 2 days) inhibits subcutaneous ovarian cancer growth in A2780 and SKOV3 mouse subcutaneous xenograft models.

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