CNDAC,135598-68-4

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CNDAC

CAS No. : 135598-68-4

MCE 国际站：CNDAC

产品活性：CNDAC 是可口服试剂 Sapacitabine (HY-16445) 的代谢物，为核苷酸类似物。CNDAC 诱导 DNA 损伤和凋亡 (apoptosis)。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Nucleoside Antimetabolite/Analog  |  Drug Metabolite  |  Apoptosis  |  DNA/RNA Synthesis

In Vitro: CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks (DSBs) when cells go through a second S phase.
Lack of Rad51D and XRCC3 sensitizes cells to CNDAC (0-1 μM; 24 h).
CNDAC (0-100 μM; 3 days) inhibits proliferation of HL-60 and THP-1 cells.
CNDAC (0-10 μM; 3-6 days) induces apoptosis in HL-60 and THP-1 cells.
CNDAC (6 μM; 48 h) induces cell cycle arrest in the G2 phase following a delayed S phase in HCT116 cells.

In Vivo: CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice.

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