- ￥990 - 3300
- MedChemExpress(MCE)
- 美国
- HY-15986
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CCT 129397
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
558640-51-0
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1664.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥990.0 |
| 规格： | 5 mg | 产品价格： | ￥1950.0 |
| 规格： | 10 mg | 产品价格： | ￥3300.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
VER-49009
CAS No. : 558640-51-0
MCE 国际站：VER-49009
产品活性：VER-49009 是一种 Hsp90 抑制剂，IC50 值为 25 nM，Kd 值为 78 nM。
研究领域：Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点：HSP
In Vitro: VER-49009 is a Hsp90 inhibitor, with an IC50 of 25 nM. VER-49009 binds to the ATPase of full length yeast Hsp90 protein, with an IC50 of 140 nM. VER-49009 inhibits Hsp90, with a Kd of 78 nM. VER-49009 also shows antiproliferative activities against various human cancer cells, with a mean GI50 of 685 ± 119 nM. VER-49009 suppressses the proliferation of human umbilical vein endothelial cells (HUVEC) with GI50 values of 444 ± 91.1 nM, and shows higher GI50s against nontumorigenic human breast (MCF10a) and prostate (PNT2) epithelial cells. VER-49009 displays no differences in cellular activities of isogenic cell lines, and these activities are independent of NQO1 expression. VER-49009 inhibits the proliferation (1, 2.5 μM), induces G2 phase arrest and reduces total Akt and phospho-Akt expression levels in CFSC cells (1-5 μM).
In Vivo: VER-49009 (4 mg/kg, i.p.) results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Endoplasmic Reticulum Stress Compound Library | Pyroptosis Compound Library | Cytoskeleton Compound Library | Anti-Prostate Cancer Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Tamoxifen | Palmitic acid | Polyinosinic-polycytidylic acid | Tanespimycin | VER-155008 | Geldanamycin | Ganetespib | Rocaglamide | Luminespib | HA15 | Novobiocin sodium | Gamitrinib TPP hexafluorophosphate | Apoptozole | Paeoniflorin | Alvespimycin hydrochloride | DTHIB | Benzbromarone | Pimitespib | HSP27 inhibitor J2 | KRIBB11 | MKT-077 | Onalespib | Col003 | MK2-IN-1 hydrochloride | BIIB021 | Pifithrin-μ | Grp94 Inhibitor-1 | HSF1A | Teprenone
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验等) 多少为好? A-6: 连接液是否需要乙醇沉淀纯化之后再转化? Q-7: T4 DNA Ligase与DNA Ligation Kit Ver.2.0 (TaKaRa Code：D6022) 的区别。 T4 RNA Ligase Q-9: T4 RNA Ligase的应用。 Q-10: 使用T4 RNA Ligase要注意哪些问题？ Q-11: 使用T4 RNA Ligase如何终止反应？ 二
, radiotherapy, heat shock, free radicals, Ca2+ and TNF etc.[45-50]. Bax is a homologous protein of Bcl-2, in the form of homopolymer or isodipolymer Bcl-2/Bax[51-54]. The ratio of Bax and Bcl-2 protein influences the apoptotic rate of cells stimulated
技术资料暂无技术资料 索取技术资料
