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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1342278-01-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥1100.0 |
| 规格： | 25 mg | 产品价格： | ￥2400.0 |
| 规格： | 50 mg | 产品价格： | ￥4000.0 |
| 规格： | 100 mg | 产品价格： | ￥6400.0 |
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RKI-1447
CAS No. : 1342278-01-6
MCE 国际站：RKI-1447
产品活性：RKI-1447是高效的 ROCK1 和 ROCK2 的小分子抑制剂，IC50 值分别为14.5 nM 和 6.2 nM。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad
作用靶点：ROCK
In Vitro: RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppresses phosphorylation of the ROCK substrates mLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of the AKT, MEK and S6 kinase at concentrations as high as 10 μM. RKI-1447 is also highly selective at inhibiting ROCK-mediated cytoskeleton re-organization. RKI-1447 inhibits migration, invasion and anchorage-independent tumor growth of breast cancer cells.
In Vivo: RKI-1447 is highly effective at inhibiting the outgrowth of mammary tumors in a transgenic mouse model. RKI-1447 inhibits mammary tumor growth by 87% and on average the mammary tumors from RKI-1447 treated mice are 7.7 fold smaller compared to those tumors from mice treated with the vehicle control.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Cytoskeleton Compound Library | Anti-Breast Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Y-27632 dihydrochloride | Chroman 1 | Belumosudil | Fasudil Hydrochloride | Thiazovivin | Narciclasine | Afuresertib | H-1152 dihydrochloride | GSK269962A | GSK429286A | Ripasudil | CCG-222740 | AT13148 | Y-33075 | LX7101 | HA-100 | GSK180736A | ROCK inhibitor-2 | SAR407899 | SR-3677 | Pentanoic acid | Verosudil | BDP5290 | CRT0066854 | Hydroxyfasudil
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文献和实验A Neurovascular BloodBrain Barrier In Vitro Model
Clin Invest 113:1447–1455, 2004), or formation of oxidative stress (Yemisci et al., Nat Med 15:1031–1037, 2009). Hence, this interdependent assembly of cells is referred to as the neurovascular unit (NVU) (Zlokovic, Nat Med 16:1370–1371, 2010; Zlokovic
0.3325 0.3318 0.3306 0.3290 0.3273 0.3253 0.3232 0.3211 3 0.2260 0.2347 0.2412 0.2460 0.2495 0.2521 0.2540 0.2553 0.2561 0.2565 4 0.1429 0.1586 0.1707 0.1802 0.1878 0.1939 0.1988 0.2027 0.2059 0.2085 5 0.0695 0.0922 0.1099 0.1240 0.1353 0.1447 0.1524
) 65122268-1447，E-mail: cmajy@public.sti.ac.cn（10）临床检验杂志（LINCHUANG JIANYAN ZAZHI，Chinese journal of clinical laboratory science）编辑部地址: 南京市中央路42号，邮编：210008电话：（025）7714280，E-mail: jcls@publicl.ptt.js.cn（11）上海医学检验杂志（SHANGHAI YIXUE JIANYAN ZAZHI，Shanghai Journal
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