L189,64232-83-3

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

L189

CAS No. : 64232-83-3

MCE 国际站：L189

产品活性：L189 是一种 DNA 连接酶抑制剂。L189 对 DNA 连接酶 I、III、IV 有抑制作用，IC₅₀ 值分别为 5 μM, 9 μM 和 5 μM。L189 无细胞毒性，单独会增加细胞死亡。L189 可被用于癌症的研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：DNA/RNA Synthesis

In Vitro: L189 inhibits DNA Ligase I, III and IV activity with IC₅₀ values of 5 μM, 9 μM and 5 μM, respectively.
L189 (5 μM, 48 h) bring good anti-proliferation activity preferentially and cause cell death by creating a cytotoxic environment.
L189 (5 μM, 48 h) reduces HeLa nuclear staining along with TMZ.
L189 (5 μM, 48 h) enhances TMZ-induced HeLa growth arrest when along with TMZ that possibly in G2/M cell cycle phase without employing cell death mechanisms.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Heterocyclic Compound Library  |  Cysteine Targeted Covalent Library  |  Cycloheximide  |  Actinomycin D  |  Oxaliplatin  |  Gemcitabine  |  Carboplatin  |  Bleomycin sulfate  |  Mitomycin C  |  Cytarabine  |  Methotrexate  |  ART558  |  Streptozotocin  |  Anisomycin  |  Fludarabine  |  Thymidine  |  Hydroxyurea  |  Remdesivir  |  Daunorubicin hydrochloride  |  Brequinar  |  Capecitabine  |  Branaplam  |  α-Amanitin  |  CX-5461  |  Folic acid  |  Urolithin A  |  Epirubicin hydrochloride  |  Plicamycin  |  Levofloxacin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds