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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
BAY-1143572 S-Enantiomer
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2250279-81-1
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2200.0 |
| 规格： | 5 mg | 产品价格： | ￥5500.0 |
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Atuveciclib S-Enantiomer
CAS No. : 2250279-81-1
MCE 国际站：Atuveciclib S-Enantiomer
产品活性：Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) 是一种有效的选择性 CDK9 抑制剂，抑制 CDK9/CycT1，IC50 为 16 nM。
研究领域：Cell Cycle/DNA Damage
作用靶点：CDK
In Vitro: In comparison with Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties, well within the limits of measurement accuracy; however, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC50: 1100 nM) .
In Vivo: Atuveciclib (BAY-1143572) S-Enantiomer exhibits blood/plasma ratios of about 1. Relative to Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar rat PK properties in vivo (CLb: 1.2 L/kg per hour, Vss: 1.2 L/kg, t1/2: 0.6 h, F: 53 %).
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