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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1246529-32-7
- 规格：
1 mg/2 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥673.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥950.0 |
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
| 规格： | 10 mg | 产品价格： | ￥2600.0 |
| 规格： | 25 mg | 产品价格： | ￥4613.0 |
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MPI-0479605
CAS No. : 1246529-32-7
MCE 国际站：MPI-0479605
产品活性：MPI-0479605 是一种有效的，选择性的，ATP 竞争性的 Mps1 抑制剂，IC50 值为 1.8 nM。
研究领域：Cell Cycle/DNA Damage | Cytoskeleton | Apoptosis
In Vitro: MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis.
In Vivo: MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI).
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文献和实验Finding Protein and Nucleotide Similarities with FASTA
Basic Protocol 1: Using the FASTA Programs Interactively Necessary ResourcesHardware A Windows 32‐bit (Windows 95
An Overview of Multiple Sequence Alignment
Gropp, W., Lusk, E., Doss, N., and Skjellum, A. 1996. A high‐performance, portable implementation of the MPI Message‐Passing Interface standard. Parallel Computing 22:789‐828.
Methylation‐Sensitive Single‐Molecule Analysis of Chromatin Structure
) 32 mM S‐adenosylmethionine (SAM; New England Biolabs) M.SssI (New England Biolabs) Nucleosome
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