J22352,2252395-44-9

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J22352

CAS No. : 2252395-44-9

MCE 国际站：J22352

产品活性：J22352 是一种具有类似靶向嵌合体蛋白水解 (PROTAC) 特性、高度选择性 HDAC6 抑制剂，其 IC₅₀ 值为 4.7 nM，J22352 通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进 HDAC6 降解和诱导抗癌效果，并通过降低 PD-L1 的免疫抑制活性，使宿主抗肿瘤活性恢复。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：HDAC

In Vitro: J22352 (0.1-20 μM; 72 hours) decreases U87MG cell viability in a dose-dependent manner.
?J22352 (10 μM; 24 hours) shows a dose-dependent decrease in HDAC6 protein abundance.

In Vivo: J22352 (10?mg/kg; given i.p. per day for 14 days in male nude mice) results in a >80% tumor growth inhibition (TGI) rate. J22352 is well tolerated in mice.

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