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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1338545-07-5
- 规格：
10 mM * 1 mL/1 mg/2 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1499.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥684.0 |
| 规格： | 2 mg | 产品价格： | ￥979.0 |
| 规格： | 5 mg | 产品价格： | ￥1588.0 |
| 规格： | 10 mg | 产品价格： | ￥2488.0 |
| 规格： | 25 mg | 产品价格： | ￥4800.0 |
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OTS964 hydrochloride
CAS No. : 1338545-07-5
MCE 国际站：OTS964 hydrochloride
产品活性：OTS964 hydrochloride 是一种口服有效的，高亲和力和选择性的 TOPK (T 淋巴因子激活的杀伤细胞起源的蛋白激酶) 抑制剂，IC50 为 28 nM。OTS964 hydrochloride 也是一种有效的细胞周期蛋白依赖激酶 CDK11 抑制剂，结合 CDK11B 的 Kd 值为 40 nM。
研究领域：Cell Cycle/DNA Damage | Apoptosis
In Vitro: OTS964 hydrochloride (10 nM; 48 hours) suppresses cancer cell proliferation.
OTS964 hydrochloride (10 nM; 48 hours) increases cancer cell death.
OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner.
In Vivo: OTS964 hydrochloride (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression.
OTS964 hydrochloride (oral administration; 50 or 100 mg/kg/day for 2 weeks) ultimately achieves complete tumor regression.
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文献和实验17,178 −0.07 19,226 17,409 −0.10 14,425 14,079 −0.02 hsa-miR-19b 13,365 9,406 −0.42 25,463 22,438 −0.13 21,532 20,625 −0.04 18,039 17,440 −0.03 hsa-miR-30e-5p 9,497 6,838 −0.39 13,045 11,321 −
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