- ￥600 - 4900
- MedChemExpress(MCE)
- 美国
- HY-108331
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
120241-79-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥1000.0 |
| 规格： | 25 mg | 产品价格： | ￥1870.0 |
| 规格： | 50 mg | 产品价格： | ￥3000.0 |
| 规格： | 100 mg | 产品价格： | ￥4900.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
3-TYP
CAS No. : 120241-79-4
MCE 国际站：3-TYP
产品活性：3-TYP 是一种 SIRT3 抑制剂 (IC50: ~377 μM)，也是甲硫氨酸氨肽酶 2 和吲哚胺 2,3-双加氧酶的抑制剂。3-TYP 可能存在许多需要检查的脱靶点，例如 NAD 依赖性酶，包括脱氢酶。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Metabolic Enzyme/Protease
作用靶点：Sirtuin | Methionine Adenosyltransferase (MAT) | Indoleamine 2,3-Dioxygenase (IDO)
In Vitro: 3-TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2- production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd.
In Vivo: 3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Necrostatin-1 | Nicotinamide | Resveratrol | Selisistat | Nicotinamide riboside chloride | Fisetin | Epacadostat | AG-270 | OSS_128167 | Suramin sodium salt | SRT 1720 | Indoximod | UBCS039 | PF-9366 | Linrodostat | AGK2 | Sirtinol | FIDAS-5 | SRT 2104 | SIRT7 inhibitor 97491 | AGI-24512 | Palmatine chloride | Thiomyristoyl | Tenovin-6 | Navoximod | MC3482 | SirReal2 | Cambinol
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
