Kira8,1630086-20-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Kira8

CAS No. : 1630086-20-2

MCE 国际站：Kira8

产品活性：Kira8 (AMG-18) 是一种单选择性 IRE1α 抑制剂，可以变构减弱 IRE1α RNase 活性，IC₅₀ 为 5.9 nM。

研究领域：Cell Cycle/DNA Damage

作用靶点：IRE1

In Vitro: Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2.

In Vivo: Male Ins2^+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks.
?One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Anti-Aging Compound Library  |  Anti-diabetic Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  Sunitinib  |  4μ8C  |  STF-083010  |  IXA4  |  MKC8866  |  KIRA6  |  Toyocamycin  |  GSK2850163  |  APY29  |  MKC3946  |  B I09  |  IXA6  |  IRE1α kinase-IN-1  |  MKC9989  |  IRE1α kinase-IN-2  |  3,6-DMAD hydrochloride  |  Z4P  |  6-Bromo-2-hydroxy-3-methoxybenzaldehyde  |  KIRA-7  |  IRE1α kinase-IN-3  |  IRE1α kinase-IN-4  |  IRE1α kinase-IN-5  |  IRE1α kinase-IN-6  |  IRE1α kinase-IN-7  |  IRE1α kinase-IN-8  |  IRE1α kinase-IN-9  |  Kira8 Hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds