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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1454925-59-7
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2300.0 |
| 规格： | 5 mg | 产品价格： | ￥5800.0 |
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NXT629
CAS No. : 1454925-59-7
MCE 国际站：NXT629
产品活性：NXT629 是一种有效、选择性、竞争性的 PPAR-α 拮抗剂，对人 PPARα 的 IC50 值为 77 nM，对其选择性高于对其他核激素受体，比如 PPARδ，PPARγ，Erβ，GR 和 TRβ，IC50 值分别为 6.0，15，15.2，32.5 和 >100 μM。NXT629 具有高效抗癌作用，在动物模型试验中，能够抑制实验性癌细胞转移。
研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor
作用靶点：PPAR
In Vitro: NXT629 (Compound 33) is a potent, selective PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, Erβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 also competitively inhibits mousse PPARα, PPARβ/δ and PPARγ, with IC50s of 2.3, 35.1, 6.9 μM, resepctively.
In Vivo: NXT629 (Compound 33; 30 mg/kg, i.p.) exhibits good pharmacokinetics in mouse, and significantly decreases Fgf21 (Fibroblast growth factor 21), a PPARα target gene in fasted mice.
?NXT629 has poor oral bioavailability in mice and rats. NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice. NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis. NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung.
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文献和实验差分析，**为有高度显著性差异(P0.05)表2各年龄组不同性别间补体C3、C4结果年龄（岁）例数补体C3（mg/dl）C4(mg/dl)20-45男50154.3±18.629.7±46.220-45女49141.8±22.925.79±4.2750-59男142152.6±30.428.4±7.0250-59女104138.8±22.225.62±7.1860-69男178152.7±22.928.00±8.4160-69女119137.9±25.624.02±9.3970-79男190148.2±24
Quantitative immunoprecipitation of GFP-fusion proteins using the GFP-Trap
in vitro binding analysis we determined that one molecule GBP binds one molecule GFP in a stable stoichiometric complex. The dissociation constant (Kd) lies with 0.59 nm within the picomolar range comparable to conventional antibodies. We further tested
2.55 4.00 9.95 3.317 ∑X 59.42 49.51 82.51 191.44 - x 4.952(2) 4.126(3) 6.876(3) 5.318 -- ∑X 2 329.1142 242.8543 629.1065 1201.0748 - 离均差平方和： 总计： 1201.0748-(191.44) 2 /36×183。0394 饲料组间
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