AZD4573,2057509-72-3

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AZD4573

CAS No. : 2057509-72-3

MCE 国际站：AZD4573

产品活性：AZD4573 是一种有效且高度选择性的 CDK9 抑制剂 (IC₅₀ 值小于 4 nM)，可用于血液恶性肿瘤的研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：CDK

In Vitro: Short-term treatment with AZD4573 led to a rapid dose- and time-dependent decrease in cellular pSer2-RNAPII, resulting in activation of caspase 3 and cell apoptosis in a broad range of haematological cancer cell lines (e.g. caspase activation EC₅₀ 13.7 nM in an acute myeloid leukemia model MV4-11) .

In Vivo: AZD4573 exhibits a short half-life in multiple species (less than one hour in rat, dog and monkey) and good solubility for intravenous administration.

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