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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1708113-43-2
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3065.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1523.0 |
| 规格： | 5 mg | 产品价格： | ￥4000.0 |
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ACY-1083
CAS No. : 1708113-43-2
MCE 国际站：ACY-1083
产品活性：ACY-1083 是一种可渗透脑的选择性 HDAC6 抑制剂，IC50 为 3 nM，ACY-1083 对 HDAC6 的选择性比其他类别的 HDAC 亚型高 260 倍。ACY-1083 可有效逆转化疗引起的周围神经病变。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：HDAC
In Vitro: Treatment with ACY-1083 (30 and 300 nM) significantly improves cell viability in a dose-dependent manner.
In Vivo: ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice
ACY-1083 (oral doses of 3 mg/kg ACY-1083 for 7 days) reverses Paclitaxel-induced mechanical allodynia in adult male SD rats.
Mice dosed with 5 mg/kg ACY-1083 by intraperitoneal (i.p.) injection have a maximum plasma concentration (Cmax) of 936 ng/mL, a half-life (T1/2) of 3.5 hours, and a biologically active plasma exposure of 8 hours after dosing.
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