GSK2643943A,2449301-27-1

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GSK2643943A

CAS No. : 2449301-27-1

MCE 国际站：GSK2643943A

产品活性：GSK2643943A 是一种靶向 USP20 的去泛素化酶 (DUB) 抑制剂。GSK2643943A 对 USP20/Ub-Rho 具有亲和力, 其 IC₅₀ 值为 160 nM。GSK2643943A 具有抗肿瘤作用，可用于口腔鳞状细胞癌 (OSCC) 的研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：Deubiquitinase

In Vitro: GSK2643943A blocks the USP20-mediated cleavage of protein-ubiquitin bonds.
?GSK2643943A (1 μM, 5 μM; overnight) renders SCC9 cells more susceptible to oHSV-1 induced oncolysis.
?GSK2643943A (1μM) leds to a notable increase of virus yields in SCC9 with 0.01 MOI T1012G infection.

In Vivo: GSK2643943A (5 mg/kg, i.p., daily, for 6 days) potentiates oHSV-1-induced oncolysis in SCC9 tumors.
?GSK2643943A (2.5 mg/kg, i.p., daily, for 9 days) plays a regulatory role in oHSV-1 T1012G replication and oncolysis in SCC7 cells.

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