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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
9-Amino-20(S)-camptothecin; 9-Amino-CPT
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
91421-43-1
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥920.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1150.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3200.0 |
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9-Aminocamptothecin
CAS No. : 91421-43-1
MCE 国际站：9-Aminocamptothecin
产品活性：9-Aminocamptothecin (9-Amino-CPT) 是拓扑异构酶 I 的抑制剂，具有有效地抗肿瘤活性。
研究领域：Cell Cycle/DNA Damage
作用靶点：Topoisomerase
In Vitro: In human breast (MCF-7), bladder (MGH-U1), and colon (HT-29) cancer cell lines, 9-Aminocamptothecin cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-Aminocamptothecin concentrations exceeds a threshold of 2.7 nm. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure.
In Vivo: 9-Aminocamptothecin (9-Amino-CPT) inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression. 9-Aminocamptothecin is well tolerated at all doses, with no toxic death or weight loss of more than 10% observed in any group. 9-Aminocamptothecin induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective. The results with this pre-clinical model support the evaluation of 9-Aminocamptothecin as antileukemic agent in a phase I trial in patients with AML.
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