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- MedChemExpress(MCE)
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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1821428-35-6
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 1 mg | 产品价格： | ￥309.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥680.0 |
| 规格： | 10 mg | 产品价格： | ￥1150.0 |
| 规格： | 25 mg | 产品价格： | ￥2260.0 |
| 规格： | 50 mg | 产品价格： | ￥3390.0 |
| 规格： | 100 mg | 产品价格： | ￥4880.0 |
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AZD0156
CAS No. : 1821428-35-6
MCE 国际站：AZD0156
产品活性：AZD0156 是一种有效的，选择性的和口服活性的 ATM 抑制剂，IC50 为 0.58 nM。AZD0156 抑制 ATM 介导的信号转导，防止 DNA 损伤检查点激活，破坏 DNA 损伤修复，并诱导肿瘤细胞凋亡 (apoptosis)。
研究领域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR | Apoptosis
In Vitro: AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
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