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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
OTX-015; MK-8628
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
202590-98-5
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1072.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥990.0 |
| 规格： | 10 mg | 产品价格： | ￥1539.0 |
| 规格： | 25 mg | 产品价格： | ￥2770.0 |
| 规格： | 50 mg | 产品价格： | ￥4156.0 |
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Birabresib
CAS No. : 202590-98-5
MCE 国际站：Birabresib
产品活性：Birabresib (OTX-015) 是一种有效的 BRD2/3/4 抑制剂，IC50 值为 92-112 nM。
研究领域：Epigenetics
作用靶点：Epigenetic Reader Domain
In Vitro: Birabresib (OTX-015) (500 nM) exposure induces a strong decrease of BRD2, BRD4 and c-MYC and increase of HEXIM1 proteins, while BRD3 expression is unchanged. c-MYC, BRD2, BRD3, BRD4?and?HEXIM1?mRNA levels do correlate however with viability following exposure to Birabresib (OTX-015).?Birabresib (OTX-015) (0.1, 1, 5 μM) treatment induces HIV-1 full-length transcripts and viral outgrowth in resting CD4+ T cells from infected individuals receiving suppressive antiretroviral therapy (ART), while exerting minimal toxicity and effects on T cell activation. Birabresib-mediated activation of HIV-1 involves an increase in CDK9 occupancy and RNAP II C-terminal domain (CTD) phosphorylation.
In Vivo: In MDA-MB-231 murine xenografts, tumor mass is significantly (p?< 0.05) reduced by Birabresib (OTX-015) (50 mg/kg) with respect to vehicle-treated animals. Birabresib (OTX-015) in combination with 2 mg/kg RAD001 shows more effective activity than Birabresib alone.
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James Hardwick CNBr Cleavage Procedure
tube containing 200 microliters of 100mg/ml CNBr in 70% formic acid. CNBr stocks are 200 milligrams/ml in 70% formic acid and are stored at -70°C. 70% formic acid is made from 98-100% formic acid and MQH2O. Optional: If you want to know
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