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- 2025年12月05日
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4°C, sealed storage, away from moisture
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货期：1-2天
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- CAS号：
2309668-29-7
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5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥437.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1150.0 |
| 规格： | 50 mg | 产品价格： | ￥2050.0 |
| 规格： | 100 mg | 产品价格： | ￥3400.0 |
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GSK-J1 lithium salt
CAS No. : 2309668-29-7
MCE 国际站：GSK-J1 lithium salt
产品活性：GSK-J1 lithium salt 是一种有效的 H3K27me3/me2-demethylases JMJD3/KDM6B 和 UTX/KDM6A 的抑制剂，对 KDM6B 的 IC50 值为 60 nM。
研究领域：Epigenetics
作用靶点：Histone Demethylase
In Vitro: GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50 of 11 μM and 94 μM, respectively.
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文献和实验The effect of lithium chloride on Lytechinus variegates embryos
that B-catenin plays a signaling role (Miller and McClay, 1997). introduction cont. Embryos that have been treated with lithium chloride accumulate B-catenin in every cell (Gilbert, 1997). LiCl inhibits GSK-3, a B
(Ser645) expression, andincreases in the total level of β-catenin and glycogen synthase protein expression were observed . 1.1.1. Inorganic Elements as Inhibitors of GSK-3 Lithium was the first discovered GSK-3 inhibitor (15
Glycogen Synthase Kinase-3 in Neurological Diseases
or indirectly by a series of neuroactive drugs including lithium and psychotropic agents. In this review, we describe the modes of regulation, the molecular targets lying downstream and the association of dysfunction of GSK-3 in various
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