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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ASN-002
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1425381-60-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2090.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1256.0 |
| 规格： | 25 mg | 产品价格： | ￥1900.0 |
| 规格： | 50 mg | 产品价格： | ￥3500.0 |
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Gusacitinib
CAS No. : 1425381-60-7
MCE 国际站：Gusacitinib
产品活性：Gusacitinib (ASN-002) 是一种口服有效的 SYK/JAK 激酶双重抑制剂，其抑制 SYK、JAK1、JAK2、JAK3 和 TYK2 的 IC50 值分别为 5, 46, 4, 11 和 8 nM。Gusacitinib 能快速且显著抑制与特应性皮炎发病机制有关的关键炎症通路。Gusacitinib 可用于慢性手部湿疹和癌症 (如基底细胞癌) 的研究。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt
In Vitro: Gusacitinib shows anti-proliferative activity in a broad panel of human cancer cell lines including DHL6, DHL4, OCI-LY10, H929, Pfeiffer, HT-1376, and Lovo, suggesting activity in both solid and hematological tumor types.
In Vivo: Gusacitinib exhibits significant efficacy in inhibiting tumor growth (>95%), in a multiple myeloma (H929) xenograft model. Gusacitinib significantly delays the onset of hind limb paralysis in the human erythroleukemia (HEL) mouse model.
Gusacitinib shows a favorable safety profile in rat and dog toxicology studies.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Obesity Compound Library | Anti-Liver Cancer Compound Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Cysteine Targeted Covalent Library | Autoimmune Disease Compound Library | Ruxolitinib | Tofacitinib | Deucravacitinib | Baricitinib | AG490 | Upadacitinib | Fedratinib | Pacritinib | Ritlecitinib | Momelotinib | WP1066 | Filgotinib | Fostamatinib | R406 | Butyzamide | Piceatannol | RO8191 | AZD-1480 | AT9283 | Peficitinib | Abrocitinib | Entospletinib | Itacitinib | Cucurbitacin I | CHZ868 | (E/Z)-Zotiraciclib | Pyridone 6 | Gandotinib
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