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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
113104-25-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1400.0 |
| 规格： | 50 mg | 产品价格： | ￥2400.0 |
| 规格： | 100 mg | 产品价格： | ￥3850.0 |
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NSC 228155
CAS No. : 113104-25-9
MCE 国际站：NSC 228155
产品活性：NSC 228155 为 EGFR 激活剂，可与 EGFR 的胞外区域结合，诱导 EGFR 的磷酸化。NSC 228155 是一种有效的 KIX-KID 相互作用抑制剂，能够抑制 CREB 的激酶诱导结构域 (KID) 和 KIX (KID 相互作用结构域，来自 CBP) 的相互作用，IC50 值为 0.36 μM。
研究领域：JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | Epigenetics
作用靶点：EGFR | Histone Acetyltransferase | Epigenetic Reader Domain
In Vitro: NSC 228155 (100 μM) enhances EGFR tyrosine phosphorylation via the action of SOD1.
NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with IC50s of 2.09 and 6.14 μM, respectively.
NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells.
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文献和实验Neurosphere and Neural Colony-Forming Cell Assays
), neural stem cells (NSC) are often isolated and studied using a culture system referred to as the neurosphere assay. Since its introduction in 1992, the neurosphere system has been used to isolate, expand, and identify the presence of an NSC population
Methods for Analysis of Brain Tumor Stem Cell and Neural Stem Cell Self-Renewal
Neural stem cells (NSC) self-renew and are multipotent, producing neurons and glia. Recent studies have shown that brain tumors (BT) contain cells that, like NSC, self-renew and are multipotent, producing the different types of cells
Since the discovery of neural stem cells (NSC) in the embryonic and adult mammalian central nervous system (CNS), there have been a growing numbers of tissue culture media and protocols to study and functionally characterize NSCs
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