MZP-54,2010159-47-2

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MZP-54

CAS No. : 2010159-47-2

MCE 国际站：MZP-54

产品活性：MZP-54 是由von Hippel-Lindau配体和BRD3/4配体相连的PROTAC，对 Brd4^BD2 的 K_d 值为 4 nM。

研究领域：PROTAC  |  Epigenetics

作用靶点：PROTACs  |  Epigenetic Reader Domain

In Vitro: MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a K_d of 4 nM for Brd4^BD2. MZP-54 binds to VHL-EloC-EloB protein (VCB) with a K_d of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC₅₀s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels.

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